Cisplatin electrolyte abnormalities

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August undefined, 2024

WebSep 1, 2024 · Cisplatin for injection can cause severe hypersensitivity reactions, including anaphylaxis and death. Manifestations have included facial edema, wheezing, … WebMay 19, 2024 · Electrolyte disorders are also related to cisplatin-induced DNA damage of thiazide-sensitive sodium-chloride co-transporter genes and to the apoptosis of distal tubule cells . Cisplatin treatment …

(PDF) Electrolyte disorders with platinum-based chemotherapy ...

WebApr 15, 2016 · 3. Platinum-containing drugs (cisplatin, carboplatin and oxaliplatin) Cisplatin, carboplatin and oxaliplatin are platinum-containing anticancer drugs targeting solid cancers, such as head and neck cancer, lung cancer, and cervical cancer (Ali et al., 2013).The use of these drugs has been associated with a number of electrolyte … WebOct 19, 2024 · Severe electrolyte abnormalities (secondary exposure) included ≥ grade three hypophosphatemia, hypokalemia, or hypomagnesemia (National Cancer Institute Common Terminology Criteria for Adverse Events v4.0). CKD was albuminuria or decreased kidney function for age (KDIGO guidelines). hydro air heating systems cost

Electrolyte disorders with platinum-based chemotherapy: …

Web5.3 Electrolyte and Metabolic Abnormalities In addition to causing hyperkalemia, spironolactone tablets can cause hyponatremia, hypomagnesemia, hypocalcemia, hypochloremic alkalosis, and hyperglycemia. Asymptomatic hyperuricemia can occur and rarely gout is precipitated. Monitor serum electrolytes, uric acid and blood glucose … WebJan 1, 2015 · Majority of electrolyte abnormalities were grade 1 for all the four electrolytes. Grade 3 (15.3%) and Grade 4 (2.4%) was seen predominantly for sodium. There were no grade 3 or 4... WebMay 18, 2024 · Compared with young patients, the incidences of cisplatin-induced nephrotoxicity and acute kidney injury (AKI) in elderly patients are significantly increased, … mass breathalyzer

Renal and electrolyte disturbances associated with cisplatin

Cisplatin dosing, indications, interactions, adverse effects …

WebFrequency not known. Alopecia; appetite decreased; asthenia; autonomic dysfunction; cardiac disorder; cerebrovascular insufficiency; deafness; dehydration; diarrhoea; … WebCisplatin is widely used in the treatment of multiple cancers, including metastatic gonadal tumors and advanced bladder cancer. ... Some cases of ventricular fibrillation have occurred in the setting of documented electrolyte abnormalities that can develop right after amsacrine administration. 85 The importance of maintaining electrolyte ... hydroair richmond vaWebSep 15, 2024 · Deafness after the initial dose of cisplatin (cisplatin injection) has been reported rarely. Ototoxic effects may be more severe in children receiving cisplatin … hydro air magna series whirlpool bath pumps

"WebHypomagnesemia may cause nausea, vomiting, sleepiness, weakness, personality changes, muscle spasms, tremors, and loss of appetite. If severe, hypomagnesemia can cause seizures Seizure Disorders In seizure disorders, the brain's electrical activity is periodically disturbed, resulting in some degree of temporary brain dysfunction. Many … " - Cisplatin electrolyte abnormalities

Cisplatin electrolyte abnormalities

Hyponatremia and other electrolyte abnormalities in patients receiving ...

Webcisplatin, and was severe in 20%. Monitor patients for hypomagnesemia, hypocalcemia, and hypokalemia prior to each dose of PORTRAZZA during treatment and for at least 8 weeks following completion of PORTRAZZA. Withhold PORTRAZZA for Grade 3 or 4 electrolyte abnormalities. Replete electrolytes as medically appropriate. (5.2) WebDec 9, 2024 · Electrolyte disorders are very common conditions in cancer patients. They mainly concern changes in serum sodium, potassium, calcium, and magnesium levels. In most cases, these alterations are asymptomatic and therefore not always taken into consideration in clinical practice.

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Webmay drive unique electrolyte disorders in different malignancies. In the next sections, the clinical fea-tures, pathophysiology, and treatment of the most … WebNational Center for Biotechnology Information

WebMay 1, 2024 · The most common diagnoses were central nervous system tumors (58 [36%]), neuroblastoma (43 [27%]), and osteosarcoma (33 [21%]). Acute kidney injury (by serum creatinine level increase) occurred in 48 of 159 patients (30%) at early cisplatin infusions and 23 of 143 patients (16%) at late cisplatin infusions. WebSep 15, 2024 · Cisplatin's side effects primarily include nephrotoxicity, gastrointestinal toxicity, neurotoxicity and ototoxicity. Cardiotoxicity is generally not defined as a side …

WebCisplatin causes hypomagnesemia in a dose-dependent fashion and affects up to 90% of patients if no preventive measures are taken ... Hypomagnesemia is the most common electrolyte abnormality related to chronic alcohol abuse and affects as many as 30% of alcohol-dependent patients. 148, ... WebNov 1, 2024 · Special attention needs to be paid to electrolyte disturbances, which should be particularly considered when administering high doses of cisplatin [19]. The most common electrolyte disorder is ...

WebMar 1, 2024 · A case of an elderly male presenting with significant recurrent hyponatremia, and prerenal azotemia, with recent exposure to cisplatin along with significant hypovolemia and urinary loss of sodium is reported. Cisplatin is a well‐known chemotherapeutic agent that can be associated with hyponatremia. It is known to be associated with a multitude …

WebManufacturer advises cisplatin requires intensive intravenous hydration and treatment may be complicated by severe nausea and vomiting. ... Side-effects Side-effects For cisplatin. Common or very common. Anaemia; arrhythmias; bone marrow failure; electrolyte imbalance; extravasation necrosis; fever; leucopenia; nephrotoxicity (dose-related and ... hydro air solutions round rockWebMay 24, 2006 · This drug should be considered among the possible causes of chronic unexplained electrolyte disorders. Cisplatin is a well-known nephrotoxic antineoplastic … hydro air technical servicesWebDec 16, 2024 · However, cisplatin-induced nephrotoxicity is a major dose-limiting factor and a significant adverse event. Mannitol is used to reduce cisplatin-induced nephrotoxicity, which is controversial. ... Diuretics contribute to electrolyte disorders, often promoting the excretion of electrolytes into urine by the kidneys. In this meta … hydroair rainbowWebCisplatin is a coordinate metal complex with significant antineoplastic activity and various effects, including acute anc chronic renal insufficiency and renal magnesium … mass breakout from azkabanWebJan 3, 2024 · A variety of kidney diseases and electrolyte disorders can result from the drugs that are used to treat malignant disease, including conventional cytotoxic agents; molecularly targeted agents, which take advantage of molecular abnormalities that drive cancer progression; and immunotherapeutic agents. mass bread and wineWebElectrolyte disorders with platinum-based chemotherapy: mechanisms, manifestations and management Platinum chemotherapy, particularly cisplatin, is commonly associated with electrolyte imbalances, including hypomagnesemia, hypokalemia, … hydro air inchttp://www.ejmanager.com/mnstemps/93/93-1446132625.pdf#:~:text=The%20most%20common%20electrolyte%20abnormality%20associated%20with%20cisplatin,the%20incidence%20of%20which%20varies%20significantly%20between%20studies. mass brickwork