WebHowever, STING deficiency (Sting gt/gt) partially prevented diet-induced adipose tissue inflammation, obesity, insulin resistance, and glucose intolerance. Conclusions: The mitochondrial damage-cGAS-STING-IRF3 pathway is critically involved in metabolic stress-induced endothelial inflammation. STING may be a potential therapeutic target for ... WebJul 11, 2024 · Aberrant activation of the cGAS-STING pathway by host DNA can lead to sterile inflammation associated with tissue damage, degeneration as well as premature aging. In this primer, we will introduce the basic principles of cGAS-STING signaling in …
STAG2 deficiency induces interferon responses via …
WebJun 30, 2024 · In this study, we found that the activation of CD8 + T cells was strikingly increased in both irradiated PD-L1-expressing primary tumor and distant non-irradiated syngeneic tumor in PD-L1-deficient mouse host, and thus enhanced radiation-induced antitumor abscopal effect (ATAE) by activating cGAS-STING pathway. WebJul 11, 2024 · Primer. cGAS–STING signaling. Cyclic GMP–AMP synthase (cGAS) and stimulator of interferon genes (STING, also known as TMEM173) constitute the major signaling pathway in vertebrates that senses non-self DNA and elicits potent immune responses. At the core of this pathway, cGAS senses double-stranded DNA (dsDNA) … green new deal cori bush
Interruption of post-Golgi STING trafficking activates tonic …
WebSep 29, 2024 · Beclin-1 interacts with cGAS and decreases STING induced IFN expression by repressing the enzymatic activity of cGAS . cGAS is required for dsDNA-induced Beclin-1 dependent autophagy . The cGAS–STING axis orchestrates ISGs and autophagy pathways to boost host immune responses to DNA viruses (93, 139–141). However, … WebApr 2, 2024 · The cGAS-STING pathway is activated in response to cytosolic DNA, and there is now increasing evidence linking excess activation of STING to pathological inflammation. Therefore, there is a strong interest in understanding this pathway in detail and developing means to inhibit the activity of the pathway pharmacologically. Lupus is a … WebThen the cGAS-STING pathway activation links nucleic acid-sensing to immune responses and pathogenic entities clearance. However, the overactivation of this signaling pathway leads to fatal immune disorders and contributes to the progression of many human inflammatory diseases. Therefore, optimal activation of this pathway is crucial for the ... green new deal city