Cytoplasmic polyadenylation
WebJun 5, 2012 · Interestingly, cytoplasmic polyadenylation waves are reinforced by positive translation feedback loops that activate the synthesis of components of the cytoplasmic polyadenylation machinery (such ... WebFeb 25, 2016 · Cytoplasmic Polyadenylation Element Binding proteins (CPEBs) are a family of polyadenylation factors interacting with 3'UTRs of mRNA and thereby regulating gene expression. Various functions of CPEBs in development, synaptic plasticity, and cellular senescence have been reported.
Cytoplasmic polyadenylation
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WebNov 24, 2015 · The cytoplasmic polyadenylation (CP) element, Pumilio binding element, and hexanucleotide polyadenylation signal are among the best understood motifs involved in CP, and translational regulation of stored transcripts as their binding partners have been relatively well-characterized. Knowledge of CP in mammalian oocytes is discussed as … WebAug 21, 2007 · Cytoplasmic polyadenylation element-binding protein 2 Short names CPE-BP2; CPE-binding protein 2; hCPEB-2 Gene names Name CPEB2 Organism names Organism Homo sapiens (Human) Taxonomic identifier 9606 NCBI Taxonomic lineage
WebAug 1, 2011 · Cytoplasmic polyadenylation is the process by which dormant, translationally inactive mRNAs become activated via the elongation of their poly (A) tails in the cytoplasm. This process is regulated by the conserved cytoplasmic polyadenylation element binding (CPEB) protein family. Recent studies have advanced our … WebFeb 6, 2024 · Cytoplasmic polyadenylation, which is one of the posttranscriptional regulations, plays a crucial role in RNA metabolism. Here, we report that Cpeb1b-mediated cytoplasmic polyadenylation is...
WebApr 20, 2024 · TENT5A is an active cytoplasmic poly (A) polymerase • Tent5a KO mice have skeletal abnormalities, including multiple fractures • Collagen type I, SerpinF1, and Sparc mRNAs are polyadenylated by TENT5A • Defect of type I collagen Tent5a KO mice is both quantitative and qualitative Summary WebCytoplasmic polyadenylation, which is one of the posttranscriptional regulations, plays a crucial role in RNA metabolism. Here, we report that Cpeb1b-mediated cytoplasmic polyadenylation is important for HSPC specification by translational control of Hedgehog (Hh) signaling during zebrafish early development.
WebJan 8, 2024 · Cytoplasmic polyadenylation, Translational regulation, Maternal mRNA, Maternal-to-zygotic transition, Zebrafish, Polysome profiling INTRODUCTION A period of transcriptional silence follows fertilization in animal embryogenesis, during which development is mainly driven by maternally deposited mRNAs and proteins ( Korzh, 2009 ).
WebMar 2, 2009 · Cytoplasmic polyadenylation is required for growth cone collapse. (A) Typical examples of collapsed and non-collapsed growth cones. (B) Cordycepin (200 μM; 3'deoxyadenosine; Cordy), but not adenosine (Adeno), blocks Sema3A-induced growth cone collapse. (C) Cordycepin does not affect lysophosphatidic acid (LPA)-induced … tru red recycleWebSep 24, 2024 · Cytoplasmic polyadenylation necessitates the RNA-binding proteins CPSF and CPEB, and can involve additional RNA-binding proteins such as … tru red reviewWebCytoplasmic polyadenylation, which is one mechanism of controlling translation, is driven by CPEB — a highly conserved, sequence-specific RNA-binding protein that binds to the cytoplasmic... tru red soft cover meeting notebookWebMar 28, 2024 · Overexpression of influenza virus NS1 protein, which inhibits nuclear polyadenylation through an interaction with the 30-kDa subunit of nuclear CPSF, … tru red scannerWebMar 31, 2024 · Critical regulatory elements that encode signals for transport, anchoring and translational regulation including signals for regulating cytoplasmic polyadenylation (cytoplasmic polyadenylation elements: CPE) are present in the 3′-untranslated region (3′UTR) of mRNA. tru red remanufactured postage cartridgeWebThe cytoplasmic polyadenylation element binding proteins are important for translation regulation, and CPEB3 is specifically responsible for binding a novel translation-regulating signal that consists of a stem-loop with a U-rich bulge. 99,100 Expression of CPEB3 occurs in a wide range of tissues and is increased in mouse hippocampus following … tru red ruled journalWebMar 30, 2024 · Further, as was the case with C12 RNA, Cl1 RNA contains a large masking element that prevents premature cytoplasmic polyadenylation during oocyte maturation. To examine the factors that may be involved in the cytoplasmic polyadenylation of both C12 and Cl1 RNAs, we performed UV cross-linking experiments in egg extracts. tru red ruled notebook