WebJan 26, 2009 · Abstract. Hemoglobin H (Hb H) disease is the most common form of thalassemia intermedia and has many features that require careful consideration in … WebHemoglobin H (HbH) Disease. HbH disease is caused by deletion of three α-globin genes. It is most common in Asian populations. With only one normal α-globin gene, the synthesis of α chains is markedly reduced, and tetramers of β-globin, called HbH, form. HbH has an extremely high affinity for oxygen and therefore is not useful for oxygen ...
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