Hepatic lectin

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WebDual roles for hepatic lectin receptors in the clearance of chilled platelets Viktoria Rumjantseva Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine The Sahlgrenska Academy, University of Gothenburg, S-413 45 Göteborg, Sweden Department of Translational Medicine WebImmune thrombocytopenia (ITP) is an acquired autoimmune disease characterized by enhanced platelet destruction and impaired platelet production from megakaryocytes. 1 ITP patients can present with no predisposing condition (hence, primary ITP) or with a variety of associated disorders (secondary ITP), 2 such as autoimmune diseases (especially …

Lectins The Nutrition Source Harvard T.H. Chan School of Public …

WebLectins. Lectins, or hemagglutinins, are an “ anti-nutrient ” that have received much attention due to popular media and fad diet books citing lectins as a major cause for obesity, chronic inflammation, and autoimmune diseases. They are found in all plants, but raw legumes (beans, lentils, peas, soybeans, peanuts) and whole grains like ... Web1 apr. 2024 · The complement system is the most important part of the innate immune system which is activated by classical, alternative and lectin pathways. It consists of more than 40 membrane and soluble proteins, including plasma complement components, soluble or membrane-type complement regulatory proteins and complement receptors (Figure 1 ). charlotte arena capacity

Soluble hepatic lectin in regenerating liver SpringerLink

WebHepatic Binding Protein: The Galactose-Specific Receptor of Mammalian Hepatocytes. Richard J. Stockert, Corresponding Author. Richard J. Stockert. Departments of Medicine and Biochemistry and the Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461. WebWe have isolated a human hepatic lectin with specificity for terminal Gal and GaINAc residues by affinity chromatography on p-aminophenyl-&D-tbiogalactosyl Sepharose. The human protein consists of a single subunit (Mr 41,000) as determined by sodium dodecyl sulfate polyacrylamide gel electrophoresis. Web1 sep. 1990 · Lee RT, Lee YC. Rabbit and rat hepatic lectins have two sugar-combining sites per monomeric unit. Biochem Biophys Res Commun. 1988 Sep 30; 155 (3):1444–1451. [Google Scholar] Lee YC, Townsend RR, Hardy MR, Lönngren J, Arnarp J, Haraldsson M, Lönn H. Binding of synthetic oligosaccharides to the hepatic Gal/GalNAc … charlotte arff

Molecular cloning of rat sperm galactosyl receptor, a C-type lectin ...

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Web17 feb. 2006 · Hepatic lectin-2 null mice [HL-2; also called asialoglycoprotein receptor (ASGPR); ref. 38] and macrophage galactose (Gal) lectin-1 (MGL-1) null mice ( 39) have been previously described. P-selectin/L-selectin doubly deficient (PL-sel null) mice and wild-type C57Bl/6J mice were from The Jackson Laboratory (Bar Harbor, ME). Web2 mei 2006 · In contrast, the major subunit of the asialoglycoprotein receptor, rat hepatic lectin-1 (RHL-1), and the Kupffer cell receptor both bind to a much broader range of oligosaccharides. Thus, the galactose-binding receptors can be divided into two specificity groups, the first group containing human SRCL and the rat macrophage galactose lectin … charlotte armstrong werth omahaWebThe Gal/GalNAc-specific lectin on the surface of rat peritoneal macrophages (macrophage asialoglycoprotein binding protein, M-ASGP-BP), which consists of a single polypeptide chain of 42 kDa, can form a homooligomeric receptor exhibiting high affinity for asialoorosomucoid (ASOR) [Ozaki K., Ii M., Itoh N., Kawasaki T. (1992) J Biol Chem … charlotte armitage yafta

"WebIdentification and tissue-expression profiling of novel chicken c-type lectin-like domain containing proteins as potential targets for carbohydrate-based vaccine strategies. Molecular ... Chick hepatic lectins: An electron microscopic study on isolated hepatocytes during development. Bioscience Reports 1991, 11 (5 ... " - Hepatic lectin

Hepatic lectin

Binding of Synthetic Oligosaccharides to the Hepatic Gal/GalNAc Lectin

WebWe surveyed the calcium-requiring (C-type) lectins in alligator liver. The major lectin purified by affinity chromatography was termed alligator hepatic lectin (AHL) and was found to be specific for mannose/L-fucose. AHL contained approximately equal amounts of 21- and 23-kDa bands upon sodium dodecyl sulfate-polyacrylamide gel electrophoresis. WebLectins are a type of protein found in all plants and animals. Different lectins can have different effects on your health. Learn which 8 foods to eat to avoid dangerous lectins.

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WebHevein is an N-acetyl-D-glucosamine (GlcNAc) specific lectin that has been hypothesized to participate in the IgE-mediated allergic reactions in patients with latex allergy. In this work we assessed the specificity and biological effect of hevein purified from rubber latex on human leukocytes, using epifluorescence microscopy and flow cytometry. Web10 apr. 2024 · The EFF-assisted lectin microarray that we developed can directly detect the surface glycans of modified EVs without destruction. We prepared various glycosidases and glycosyltransferases for glycan engineering to obtain EVs with four types of surface glycan patterns: sialic acid, galactose, N-acetylglucosamine, and mannose.

WebHepatic lectin is a membrane receptor protein that recognizes and binds exposed N-acetylglucosamine moieties of plasma glycoproteins, thus mediating their clearance (from the circulation) and endocytosis. GO annotations Expand table Complete GO annotation on QuickGO Keywords Molecular function # Receptor Biological process # Endocytosis Ligand Webwhen hepatic lectins were blocked with competitive glycoeonjugates, tumor cell colonization of the liver could be prevented in two different model systems. Introduction In many tumor systems lung and liver are the organs most frequently involved in the formation of secondary tumor colonies.

WebThe mammalian hepatic ASGPR mediate the endocytosis and degradation of serum proteins from which terminal sialic residues have been removed. The rat asialoglycoprotein receptor (ASGPR) consists of three polypeptide subunits: rat hepatic lectin (RHL)-1, … WebRat sperm galactosyl receptor is a member of the C-type animal lectin family showing preferential binding to N-acetylgalactosamine compared to galactose. Binding is mediated by a Ca2+-dependent carbohydrate-recognition domain (CRD) identical to that of the minor variant of rat hepatic lectin receptor 2/3 (RHL-2/3).

Web1 nov. 1995 · Lectin Histochemistry and Carcinoembryonic Antigen in Spontaneous Colonic Cancers of Cotton-top Tamarins ( Saguinus oedipus) M. Brack Preview abstract PDF / EPUB Pasteurella multocida Free access Research article First published November 1, 1995 pp. 674–682

Web10 okt. 2024 · In rodents, leptin signaling in the brain increases very-low-density lipoprotein triglyceride (VLDL-TG) secretion and reduces hepatic lipid content via the vagus nerve. In this randomized, placebo-controlled crossover trial (EudraCT Nr. 2024-003014-22), we tested whether a comparable mechanism regulates hepatic lipid metabolism in humans. charlotte aronofskyWeb16 sep. 2024 · The process could be specifically inhibited by the neoglycoprotein Gal44-AI-bovine serum albumin, or by IgG specific for the hepatic lectin, but not by preimmune IgG. charlotte armstrong leigh dayWeb18 jul. 2024 · Proteomic analyses showed that mannan-binding lectin serine protease 1 (MASP1) was enriched in hepatocyte-derived small EVs and activated HSCs via p38 MAPK/ATF2 signaling. ARRB1 upregulated MASP1 ... charlottearonoffWeb8 aug. 2024 · Primary hepatocytes and HSCs were isolated, and human hepatic LO2 and stellate LX2 cells were used. Small extracellular vesicles (EVs) were purified, and key proteins were identified. ARRB1 was up-regulated in hepatocytes and associated with autophagic blockage in liver fibrosis. charlotte arnould artisteWebParticular Authoritative of N-acetylglucosamine to the Chicken Hepatic Lectin Yamuna.V Department of Pharmacology, Pullareddy institute of Pharmacy, Hyderabad, India Among Ca2+-dependent (C-type) creature lectins, the chicken hepatic lectin (CHL) is special in showing nearly total selectivity charlottearthistory tumblrWebBinding characteristics of N-acetylglucosamine-specific lectin of the isolated chicken hepatocytes: similarities to mammalian hepatic galactose/N-acetylgalactosamine-specific lectin. Biochemistry 1989, 28 (21) , 8351-8358. charlotte arrivals todayWebThe parameters that affect the interaction of ligands with a fucose-binding lectin from rat liver have been examined. 125I-Fucosyl-bovine serum albumin (Fuc-BSA) containing 50 residues of fucose/molecule was used as the standard ligand. At low initial concentrations of ligand (10 ng/ml) and lectin (140 ng/ml), the reaction reaches equilibrium at pH 7.8, 23 … charlotte arrhythmia center