How does daptomycin cause myopathy

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August undefined, 2024

WebPatients often have muscle stiffness or weakness. Myositis: This is a type of myopathy that causes inflammation of your muscles, leading to weakness, swelling and pain. Many people with a myopathy, including myositis, manage their symptoms and lead active lives. Medications can often relieve symptoms. WebMar 1, 2024 · Bloating or swelling of the face, arms, hands, lower legs, or feet fever tingling of the hands or feet unusual weight gain or loss Less common Agitation black, tarry stools bladder pain bloody or cloudy urine blurred vision chest pain, discomfort, or tightness chills confusion cough decreased awareness or responsiveness

Daptomycin Injection: MedlinePlus Drug Information

WebComment: Coadministration of daptomycin with HMG-CoA reductase inhibitors may increase CPK levels and risk for myopathy; consider temporary suspension of HMG-CoA … WebJan 28, 2024 · new or worsening cough , fever, trouble breathing, unexplained muscle pain, tenderness, and. weakness. Rare side effects of Daptomycin include: none. This is not a … greatest showman suit

Myopathy Associated with Daptomycin Use 2006-09-01

WebDaptomycin. Daptomycin is a cyclic lipopeptide antibiotic that has a unique mechanism of action. It binds to the bacterial cell membranes, causing rapid depolarization of the … WebJun 15, 2006 · The use of daptomycin has been associated with an elevation in creatine phosphokinase level, with a reported incidence of 2.8% in phase III clinical trials. Published case reports have documented the presence of myopathy in patients who received daptomycin; however, there have been no previously reported cases of rhabdomyolysis in … WebFeb 28, 2024 · A drug-induced myopathy is defined as the manifestation of myopathic symptoms occurring in patients without prior muscle disease when exposed to certain … flipping homes business plan

Daptomycin-Induced Hyperkalemia as an Early Sign of ... - PubMed

Side Effects of Cubicin (Daptomycin Injection), Warnings, Uses - RxList

WebWhile the statins are effective in providing protection from coronary and cardiovascular events, they are known to cause myopathy (usually dose-related) and, rarely, rhabdomyolysis. 1 A clinical diagnosis of myopathy is made when there is muscle pain or weakness accompanied by a creatine kinase (CK) level more than ten times the upper … WebDaptomycin injection comes as a powder to be added to fluid and injected into a vein by a doctor or nurse. It is usually given once a day. The length of your treatment depends on … greatest showman theatre productionWebDaptomycin has excellent coverage against gram-positive bacteria. The adverse effect profile has included rare reports of myopathy and elevated CK levels. Daptomycin is a … greatest showman streaming platform

"WebDaptomycin. Daptomycin is a lipopeptide that targets bacterial cell membranes and has been successfully used to treat skin and soft tissue infections caused by Gram-positive bacteria, including E. faecalis species. ... The primary toxicity seen is a dose-dependent, reversible myopathy that can be monitored by elevation in serum creatinine ... " - How does daptomycin cause myopathy

How does daptomycin cause myopathy

Myopathy Associated with Daptomycin Use 2006-09-01

WebClinically relevant plasma concentrations of daptomycin reported to cause a significant concentration-dependent false prolongation of prothrombin time (PT) and elevation of International... WebMar 21, 2024 · Bloating or swelling of the face, arms, hands, lower legs, or feet fever tingling of the hands or feet unusual weight gain or loss Less common Agitation black, tarry …

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WebMar 7, 2024 · Cubicin may cause serious side effects including: hives, difficulty breathing, swelling of your face, lips, tongue, or throat, severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose), … WebJun 15, 2006 · Given the temporal relationship between daptomycin initiation and elevation in CPK level, daptomycin was identified as the offending agent and was discontinued. …

WebDec 11, 2024 · Daptomycin is associated with an increased incidence of myopathy and rhabdomyolysis. There have been cases reported in patients with and without acute renal … WebMar 10, 2024 · Myopathy, defined as muscle aching or muscle weakness, in conjunction with increased serum CK concentrations up to 10 times ULN reported in patients receiving daptomycin. ... Daptomycin causes concentration-dependent false prolongation of the PT and elevated INR if certain recombinant thromboplastin reagents are used for these tests.

WebNov 24, 2024 · It is less nephrotoxic than vancomycin. It has a unique bactericidal mechanism through destruction of bacterial membrane potential. However, one of the … WebNov 23, 2024 · Daptomycin must be mixed with a liquid (diluent) before using it. Prepare your injection only when you are ready to give it. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine. You may need frequent blood and urine tests. daptomycin may cause false results with certain medical tests.

WebNov 24, 2024 · It is less nephrotoxic than vancomycin. It has a unique bactericidal mechanism through destruction of bacterial membrane potential. However, one of the most clinically relevant adverse effects of daptomycin is reversible myopathy, especially when daptomycin is used in high doses.

WebDaptomycin: Temporarily suspend simvastatin: Grapefruit juice: Avoid grapefruit juice ... Simvastatin occasionally causes myopathy manifested as muscle pain, tenderness or weakness with creatine kinase (CK) above ten times the upper limit of normal (ULN). Myopathy sometimes takes the form of rhabdomyolysis with or without acute renal failure … greatest showman svgWebMar 21, 2024 · Daptomycin may cause a kidney problem called tubulointerstitial nephritis. Check with your doctor right away if you have a bloody or cloudy urine, fever, skin rash, … flipping homes in austinWebMar 7, 2024 · dizziness, trouble sleeping (insomnia), anxiety, itching or skin rash, increased sweating, or. injection site reactions (pain, discomfort, irritation, redness, or swelling). Tell your doctor if you have serious side effects of Cubicin including: muscle pain/cramps/weakness, numbness or tingling of hands or feet, flipping homes chicago september 8WebRhabdomyolysis is a known possible complication associated with daptomycin therapy. However, previous findings were predominantly in phase 1 and 2 trials, and the effects … flipping homes companies wsjWebDec 19, 2024 · In this retrospective, case-control study, both myopathy and rhabdomyolysis were increased by coadministration. Daptomycin has been associated with clinical myopathy in 2% to 14% of patients. Similarly, statins are associated with myopathy in 5% to 10% of patients. Although prior reports suggested no increased risk for myopathy when … flipping homes chicago september 2018WebMar 7, 2024 · Daptomycin is a lipopeptide antimicrobial with activity against gram-positive organisms, including antimicrobial-resistant pathogens such as methicillin-resistant … greatest showman the greatest show songWebMar 1, 2024 · Daptomycin injection is used to treat complicated skin and skin structure infections (cSSSI). It is also used to treat infections in the bloodstream (bacteremia), including right-sided infective endocarditis. Daptomycin belongs to the class of medicines known as antibiotics. It works by killing bacteria or preventing their growth. flipping homes finding contractors