WebJan 15, 2024 · Figure 4. Prolyl hydroxylase inhibitor (PHI) FG4592 enhances the expression of osteochondrogenic markers that is inhibited by zinc. VSMCs were cultured in growth medium in the presence or absence of PHI FG4592 (5 and 20 μmol/L) or in calcification medium with or without PHI and zinc for 10 days, ... WebJan 2, 2014 · Collagen prolyl-4-hydroxylase α subunit 2 (P4HA2), an enzyme hydroxylating proline residues in -X-Pro-Gly- sequences, is a potential therapeutic target for the disorders associated with increased collagen deposition. However, expression and function of P4HA2 in breast cancer progression are not well investigated. Methods
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WebMar 16, 2024 · For NDD-CKD patients, HIF-PHIs could ameliorate functional iron deficiency by promoting iron transport and utilization, which may be achieved by decreasing hepcidin … WebJan 15, 2016 · Ethyl 3,4-dihydroxybenzoate (EDHB) is commonly used as a "P4H" inhibitor in cells, but suffers from low potency, poor selectivity, and off-target effects that cause iron … the hooded men 1971 wikipedia
Prolyl hydroxylase Sigma-Aldrich
WebSep 15, 2014 · The hydroxylation of HIF-α is catalyzed by HIF prolyl 4-hydroxylase (P4H) isoenzymes 1–3 (also known as PHDs 1–3 and EglNs 2, 1, and 3) (1–6) and a … WebApr 25, 2000 · Here, we report that the C. elegans genome possesses two genes that encode α subunits of prolyl 4-hydroxylase. We have generated a deletion mutant of each gene and explored their biological roles. One gene, dpy-18, is essential for wild-type body morphology; the other, phy-2, is required for dpy-18 mutant viability, and vice versa. We have also … WebOct 26, 2024 · Collagen prolyl 4-hydroxylase (P4H) is an α 2 β 2 tetrameric α-ketoglutarate (α-KG)-dependent dioxygenase that catalyzes 4-hydroxylation of proline to promote … the hooded man photograph